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Funded by the Spanish Ministry of Economy and Competitiveness-FEDER (BFU2013-47688-P; BFU2016-77691-C2-2-P and C2-1-P) and the Generalitat Valenciana (PROMETEO/2016/076). B.C.-M. is a predoctoral fellow of the "Becas Chile" program of the Government of Chile. C.P.-B. is a predoctoral fellow of the "Atraccio de Talent" program of the University of Valencia. M.A.-A is a fellow of the "Programa de Empleo Joven" PEJ-2014-A-63220 of the Spanish Government.

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Abellán-álvaro, MariaAuthor

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June 13, 2025
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Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Publicated to:Journal Of Comparative Neurology. 525 (13): 2929-2954 - 2017-09-01 525(13), DOI: 10.1002/cne.24248

Authors: Cadiz-Moretti, Bernardita; Abellan-Alvaro, Maria; Pardo-Bellver, Cecilia; Martinez-Garcia, Fernando; Lanuza, Enrique

Affiliations

Univ Jaume 1, Fac Ciencies Salut, Unitat Mixta Neuroanat Func UV UJI, Unitat Predept Med, Castellon de La Plana, Spain - Author
Univ Valencia, Fac Ciencias Biol, Dept Biol Cellular & Biol Func, Unitat Mixta Neuroanat Func UV UJI, E-46100 Valencia, Spain - Author

Abstract

The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, partially due to a lack of knowledge of its connectivity. In this work, we describe the pattern of afferent and efferent projections of the ACo by using fluorogold and biotinylated dextranamines as retrograde and anterograde tracers, respectively. The results show that the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with the chemosensory and basomedial amygdala. In addition, it receives dense projections from the midline and posterior intralaminar thalamus, and moderate projections from the posterior bed nucleus of the stria terminalis, mesocortical structures and the hippocampal formation. Remarkably, the ACo projects moderately to the central nuclei of the amygdala and anterior bed nucleus of the stria terminalis, and densely to the lateral hypothalamus. Finally, minor connections are present with some midbrain and brainstem structures. The afferent projections of the ACo indicate that this nucleus might play a role in emotional learning involving chemosensory stimuli, such as olfactory fear conditioning. The efferent projections confirm this view and, given its direct output to the medial part of the central amygdala and the hypothalamic aggression area', suggest that the ACo can initiate defensive and aggressive responses elicited by olfactory or, to a lesser extent, vomeronasal stimuli.

Keywords

2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt5-hydroxysulfadimidineAccessory olfactory-bulbAfferent pathwaysAnimalsAxonal tracingBed nucleiBiotinBiotinylated dextran amineCerebral hemisphere integrationChemosensory amygdalaCorticomedial nuclear complexDextransEfferent pathwaysFemaleFluorogoldIntrinsic connectionsMedial amygdalaMiceOlfactory systemPha-lPhaseolus-vulgaris-leukoagglutininPiriform cortexRat-braiRrid: ab_90738StilbamidinesStria terminalisSulfamethazineVomeronasaVomeronasal

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Comparative Neurology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2017, it was in position 6/167, thus managing to position itself as a Q1 (Primer Cuartil), in the category Zoology. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.86, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 21
  • Europe PMC: 16

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 58.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 59 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 57.75.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).
  • The number of mentions on Wikipedia: 1 (Altmetric).
  • The number of mentions in news outlets: 7 (Altmetric).