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Satue, KAuthorDomingo, RAuthor

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August 2, 2016
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Longitudinal study of the renin angiotensin aldosterone system in purebred Spanish broodmares during pregnancy

Publicated to:Theriogenology. 75 (7): 1185-94-1194 - 2011-04-15 75(7), DOI: 10.1016/j.theriogenology.2010.11.029

Authors: Satue, K; Domingo, R

Affiliations

Cardenal Herrera Univ, Fac Vet Med, Dept Anim Med & Surg, Valencia, Spain - Author
Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Cardenal Herrera University, Valencia, Spain. ksatue@uch.ceu.es - Author

Abstract

During pregnancy, the coordinated interaction of the components of the renin-angiotensin-aldosterone system (RAAS) plays a vital role in accommodating the cardiovascular, haemodynamic and haematological needs imposed by foetal development and the placenta. This significantly influences the birth weight of the neonate and foetal viability. Although the evolution of each of the components of this system has been widely described in various species, it has not yet been clarified in the mare. Thus, the objectives of the present research were: 1) to establish reference values for renin (REN), angiotensin II (ANG-II) and aldosterone (ALD) concentrations in Spanish broodmares, and 2) to analyse the evolution of the aforementioned components during pregnancy. Thirty-one Purebred Spanish broodmares aged between 5 and 15 years old were studied for 11 months of pregnancy and compared to a control group composed of 11 non-pregnant Spanish mares. Morning venous blood samples were drawn on a monthly basis during pregnancy and pre-treated to prevent degradation until subsequent analysis. Serum REN, ANG-II and ALD concentrations were analysed by competitive immunoassay. This study found that pregnancy in Purebred Spanish broodmares is characterised by a gradual increase in REN concentrations, variable fluctuations in ALD concentrations, and no significant modifications in ANG-II concentrations. These results could provide potentially valuable information in understanding the physiological basis of the RAAS in mares, since we have been able to establish specific reference ranges for these components, as well as obtaining information on their evolution during pregnancy. As is often the case in other animal species, the increase in RAAS activity is a natural physiological process that occurs during pregnancy in Spanish broodmares. This may also be related to certain metabolic and hormone responses that contribute to the control of homeostasis in pregnant mares.Copyright © 2011 Elsevier Inc. All rights reserved.

Keywords

HorseMarePregnancyRenin angiotensin ii aldosterone system

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Theriogenology due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2011, it was in position 16/144, thus managing to position itself as a Q1 (Primer Cuartil), in the category Veterinary Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.39, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Sep 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-09-12, the following number of citations:

  • WoS: 11
  • Scopus: 13
  • Europe PMC: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-09-12:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 14 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Satue Ambrojo, Katiuska) and Last Author (Domingo Ortiz, Rosana).