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Development of a multiparametric cell-based protocol to screen and classify the hepatotoxicity potential of drugs

Publicated to:Toxicological Sciences. 127 (1): 187-198 - 2012-05-01 127(1), DOI: 10.1093/toxsci/kfs083

Authors: Tolosa, Laia; Pinto, Sandra; Teresa Donato, M; Lahoz, Agustin; Castell, Jose V; Enrique O'Connor, J; Jose Gomez-Lechon, M

Affiliations

Centro de Investigacion Biomedica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Fondo de Investigaciones Sanitarias (FIS), Barcelona 08036, Spain - Author
Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain - Author
FIS, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona 08036, Spain - Author
Hosp La Fe, Ctr Invest, Unidad Hepatol Expt, Inst Invest Sanitaria, E-46009 Valencia, Spain - Author
Laboratorio de Citómica, Unidad Mixta Centro de Investigación Príncipe Felipe, Universidad de Valencia Estudi General (CIPF-UVEG), 46013 Valencia, Spain - Author
Unidad de Hepatología Experimental, Centro de Investigación, Instituto de Investigación Sanitaria Hospital La Fe, 46009 Valencia, Spain - Author
Univ Valencia Estudi Gen CIPF UVEG, Ctr Invest Principe Felipe, Unidad Mixta, Lab Citom, Valencia 46013, Spain - Author
Univ Valencia, Dept Bioquim & Biol Mol, Fac Med, Valencia 46010, Spain - Author
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Abstract

Keywords

2 nitrofluorene2,4 dinitrophenolAcetylsalicylic acidAflatoxin b1AmfebutamoneAmikacinAmiodaroneAmitriptylineAnimal testing alternativesArticleAtropineAzathioprineCalcium cell levelCalcium signalingCaptoprilCarbamazepineCell assayCell damageCell membraneCell membrane permeabilityCell nucleusCell strain hepg2Cell structureChloramphenicolChloroquineChlorpromazineClassificationClozapineColchicineControlled studyCumene hydroperoxideCycloheximideCyclosporin aDiclofenacDigoxinDoxycyclineDrugDrug-induced liver injuryErythromycinEtoposideFenofibrateFialuridineFluorescent dyeHep g2 cellsHepatocytesHepatotoxicityHigh-throughput screening assaysHumanHuman cellHumansIn vitro studyLiver toxicityMechanismMitochondria, liverOxidative stressParacetamolPredictive value of testsReproducibility of resultsScreeningToxicity testsUnindexed drugXenobiotic stressXenobiotics

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Toxicological Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 8/85, thus managing to position itself as a Q1 (Primer Cuartil), in the category Toxicology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.89. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.28 (source consulted: FECYT Feb 2024)
  • Field Citation Ratio (FCR) from Dimensions: 9.81 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-18, the following number of citations:

  • WoS: 100
  • Scopus: 117
  • Europe PMC: 61
  • OpenCitations: 103

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-18:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 100.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 100 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 9.