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10

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Ministerio de Ciencia e Innovacion, Grant/Award Number: PGC2018-101910-B-I00

Analysis of institutional authors

Marfull-Oromí PAuthorBallester-Lurbe BAuthor or co-author of article in journal with external admissions assessment committeePérez-Roger IAuthor

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February 21, 2021
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Genetic ablation of the Rho GTPase Rnd3 triggers developmental defects in internal capsule and the globus pallidus formation

Publicated to:Journal Of Neurochemistry. 158 (2): 197-216 - 2021-07-01 158(2), DOI: 10.1111/jnc.15322

Authors: Marfull-Oromi, Pau; Fleitas, Catherine; Zammou, Bahira; Rocandio, Daniel; Ballester-Lurbe, Begona; Terrado, Jose; Perez-Roger, Ignacio; Espinet, Carme; Egea, Joaquim

Affiliations

‎ Univ CEU Cardenal Herrera, Fac Vet, Dept Med & Cirugia Anim, Valencia, Spain - Author
‎ Univ Lleida, IRBLLEIDA, Avda Rovira Roure 80, Lleida 25198, Spain - Author
‎ Univ Lleida, IRBLLEIDA, Serra Hunter Associate Prof, Lleida, Spain - Author

Abstract

The forebrain includes the cerebral cortex, the thalamus, and the striatum and globus pallidus (GP) in the subpallium. The formation of these structures and their interconnections by specific axonal tracts take place in a precise and orchestrated time and spatial-dependent manner during development. However, the knowledge of the molecular and cellular mechanisms that are involved is rather limited. Moreover, while many extracellular cues and specific receptors have been shown to play a role in different aspects of nervous system development, including neuron migration and axon guidance, examples of intracellular signaling effectors involved in these processes are sparse. In the present work, we have shown that the atypical RhoGTPase, Rnd3, is expressed very early during brain development and keeps a dynamic expression in several brain regions including the cortex, the thalamus, and the subpallium. By using a gene-trap allele (Rnd3gt ) and immunological techniques, we have shown that Rnd3gt/gt embryos display severe defects in striatal and thalamocortical axonal projections (SAs and TCAs, respectively) and defects in GP formation already at early stages. Surprisingly, the corridor, an important intermediate target for TCAs is still present in these mutants. Mechanistically, a conditional genetic deletion approach revealed that Rnd3 is primarily required for the normal development of Medial Ganglionic Eminence-derived structures, such as the GP, and therefore acts non-cell autonomously in SAs and TCAs. In conclusion, we have demonstrated the important role of Rnd3 as an early regulator of subpallium development in vivo and revealed new insights about SAs and TCAs development.© 2021 International Society for Neurochemistry.

Keywords

AnimalsAxon guidanceAxonsBrainBrain chemistryCorridorGene deletionGene expression regulation, developmentalGlobus pallidusIntermediate targetInternal capsuleMedian eminenceMiceMice, inbred c57blMice, knockoutNeostriatumNeural pathwaysRho gtp-binding proteinsRnd3 protein, mouseStriatal axonsSubpallium developmentThalamocortical axons

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Neurochemistry due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-13:

  • WoS: 4
  • Scopus: 3
  • Europe PMC: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 11.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 11 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 8.25.
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Terrado Vicente, José) .