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Grant support

This work was supported by project FIS PI17-00728 (Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Ministerio de Economia y Competitividad, Spain), cofunded by the European Regional Development Fund of the European Union: a Way to Making Europe, and Project PID2019-104439RB-C21/AEI/10.13039/501100011033. The stay of I.G.M at the Hospital Universitario Central de Asturias was funded by a grant from the 'Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica' (SEIMC).

Analysis of institutional authors

Garcia-Menino, IAuthor

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June 2, 2021
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Article

Spread of OXA-48-producing Klebsiella pneumoniae among COVID-19-infected patients: The storm after the storm

Publicated to:Journal Of Infection And Public Health. 14 (1): 50-52 - 2021-01-01 14(1), DOI: 10.1016/j.jiph.2020.11.001

Authors: Garcia-Menino, Isidro; Forcelledo, Lorena; Rosete, Yaiza; Garcia-Prieto, Emilio; Escudero, Dolores; Fernandez, Javier

Affiliations

‎ Hosp Univ Cent Asturias, Serv Med Intens, Oviedo, Spain - Author
‎ Hosp Univ Cent Asturias, Serv Microbiol, Ave Roma S-N, Oviedo 33011, Spain - Author
‎ iAST, Res & Innovat Artificial Intelligence & Stat Dept, Oviedo, Spain - Author
‎ Inst Invest Sanitaria Principado Asturias ISPA, Grp Invest Traslac Paciente Crit, Oviedo, Spain - Author
‎ Inst Invest Sanitaria Principado Asturias ISPA, Grp Microbiol Traslac, Oviedo, Spain - Author
‎ Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago, Spain - Author
‎ Univ Santiago de Compostela USC, Fac Vet, Dept Microbiol & Parasitol, Lab Referenda Escherichia Coli LREC, Lugo, Spain - Author
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Abstract

The impact of secondary infections by multidrug-resistant bacteria in COVID-19 infected patients has yet to be evaluated. Here, we report the clinical and molecular features of an outbreak of seven patients carrying CTX-M-15- and OXA-48-producing Klebsiella pneumoniae belonging to ST326 during COVID19 pandemic in an ICU in northern Spain. Those patients were admitted to beds close to each other, two of them developed ventilator-associated pneumonia (VAP), one exhibited primary bacteremia and the remaining four were considered to be colonized. None of them was colonized prior to admission to the ICU an all, except one of those who developed VAP, were discharged. Hydroxychloroquine and lopinavir/ritonavir were administered to all of them as COVID-19 therapy and additionally, three of them received tocilizumab and corticosteroids, respectively. Reusing of personal protective equipment due to its initial shortage, relaxation in infection control measures and negative-pressure air in ICU rooms recommended for the protection of health care workers (HCWs), could have contributed to this outbreak. Maximization of infection control measures is essential to avoid secondary infections by MDR bacteria in COVID-infected patients. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.

Keywords

covid-19icuk. pneumoniaeoxa-48AgedBeta-lactamasesCovid-19Cross infectionDrug resistance, multiple, bacterialFemaleHumansIcuIntensive care unitsK. pneumoniaeKlebsiella infectionsKlebsiella pneumoniaeMaleOxa-48OxacillinaseSars-cov-2Secondary infectionsSpain

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Journal Of Infection And Public Health due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 27/210, thus managing to position itself as a Q1 (Primer Cuartil), in the category Public, Environmental & Occupational Health.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.66. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 6.75 (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 24
  • Europe PMC: 19

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 149.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 144 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.4.
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (García Abad, Isidro) .